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Clinical practice guidelines for the diagnosis and management of prosthetic joint infection have been produced by a range of organizations. Guidelines stress the importance of multi-disciplinary working and of adopting a methodical approach. This includes careful assessment of the patient's surgical, medical and psychosocial problems, rational investigation, a decision-making framework for surgery and targeted, sometimes prolonged, use of intravenous or highly bioavailable oral antibiotics. Despite limited high-quality evidence, adoption of clinical guidelines can improve practice by reducing variation and by establishing conditions for the subsequent conduct of multicentre studies or systematic reviews.

Original publication




Journal article


J Antimicrob Chemother

Publication Date



69 Suppl 1


i29 - i35


consensus, guidelines, management, multi-disciplinary, Anti-Bacterial Agents, Debridement, Humans, Osteoarthritis, Practice Guidelines as Topic, Prosthesis-Related Infections