Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Surgical reattachments of tendon to bone in the rotator cuff are reported to fail in around 40% of cases. There are no adequate solutions to improve tendon healing currently available. Electrospun, sub-micron materials, have been extensively studied as scaffolds for tendon repair with promising results, but are too weak to be surgically implanted or to mechanically support the healing tendon. To address this, we developed a bonding technique that enables the processing of electrospun sheets into multi-layered, robust, implantable fabrics. Here, we show a first prototype scaffold created with this method, where an electrospun sheet was reinforced with a woven layer. The resulting scaffold presents a maximum suture pull out strength of 167N, closely matched with human rotator cuff tendons, and the desired nanofibre-mediated bioactivity in vitro and in vivo. This type of scaffold has potential for broader application for augmenting other soft tissues.

Original publication




Journal article


Acta Biomater

Publication Date





124 - 135


Electrospinning, Implant, Layering, Polydioxanone, Rotator cuff, Tendon, Aged, Elastic Modulus, Electroplating, Equipment Design, Equipment Failure Analysis, Female, Guided Tissue Regeneration, Humans, In Vitro Techniques, Male, Middle Aged, Rotator Cuff, Rotator Cuff Injuries, Stress, Mechanical, Surgical Mesh, Tendon Injuries, Tensile Strength, Tissue Scaffolds, Treatment Outcome