Aldehyde-mediated inhibition of asparagine biosynthesis has implications for diabetes and alcoholism
John T., Saffoon N., Walsby-Tickle J., Hester SS., Dingler FA., Millington CL., McCullagh JSO., Patel KJ., Hopkinson RJ., Schofield CJ.
Asparagine levels are reduced in patients with diabetes and alcoholism. A plausible mechanism is that aldehydes elevated in these diseases react with the N-terminal cysteine of asparagine synthetase B, so inhibiting asparagine production.