Professor Guy Thwaites
Contact information
Podcast interview
Tuberculosis meningitis
Tuberculosis meningitis affects a fractions of TB patients but causes high levels of mortality and morbidity. A recent trial at OUCRU showed that aspirin can greatly improve outcomes. Such trial is typical of the work done in our Vietnam units, where all the research is focussed on improving the outcome for patients directly.
Colleges
Guy Thwaites
Professor of Infectious Diseases
Guy Thwaites is an academic infectious diseases physician and clinical microbiologist. He has a global research focus on life-threatening infections, especially tuberculosis and tuberculous meningitis, aiming to translate high-quality clinical trials and mechanistic science into better outcomes and policy. Guy lived and worked in southeast Asia for 17 years. He was Director of the Oxford University Clinical Research Unit (OUCRU), a Wellcome Trust Major International Programme, from October 2013 to January 2026. OUCRU conducts interdisciplinary research across Vietnam, Indonesia, and Nepal. Guy has spent the last 20 years building and leading large international teams and partnerships spanning governments, hospitals, WHO, and industry. He was appointed MBE for services to public health and Vietnam–UK relations in 2021, and is a Fellow of the Academy of Medical Sciences.
Recent publications
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Sotrovimab versus usual care in patients admitted to hospital with COVID-19: a randomised, controlled, open-label, platform trial (RECOVERY)
Journal article
Horby PW. et al, (2025), Lancet Infectious Diseases
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Fatal Mycobacterium avium meningitis in an HIV-negative Vietnamese man: a case report.
Journal article
Nguyen VT. et al, (2025), J Med Case Rep, 19
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Molnupiravir or nirmatrelvir-ritonavir plus usual care versus usual care alone in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.
Journal article
RECOVERY Collaborative Group None., (2025), Lancet Infect Dis
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Treatment options to support the elimination of hepatitis C: an open-label, factorial, randomised controlled non-inferiority trial.
Journal article
Cooke GS. et al, (2025), Lancet
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Effectiveness and safety of shortened intensive treatment for children with tuberculous meningitis (SURE): a protocol for a phase 3 randomised controlled trial evaluating 6 months of antituberculosis therapy and 8 weeks of aspirin in Asian and African children with tuberculous meningitis.
Journal article
Huynh J. et al, (2025), BMJ Open, 15