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Spin and fragility are common in randomised controlled trials published in anaesthesia journals. Staying with the facts and addressing only the primary endpoint in the conclusion of clinical research reports might help reduce spin. Routinely reporting the fragility index, in turn, could deliver information about robustness, enhancing the transparency of positive dichotomous results. It is in the best interest of clinical research that authors, reviewers, and journals come together to reduce spin and address the fragility of randomised controlled trials.

Original publication

DOI

10.1016/j.bja.2023.02.021

Type

Journal article

Journal

Br J Anaesth

Publication Date

05/2023

Volume

130

Pages

507 - 510

Keywords

binary outcomes, fragility, randomised controlled trial, robustness, spin, trial design, Humans, Anesthesia, Anesthesiology, Anesthetists, Randomized Controlled Trials as Topic