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Forecasting how best to control and eliminate Neglected Tropical Diseases
Innovation Making a Difference Partnerships Research
26 April 2024
Neglected tropical diseases (NTDs) are a major cause of death, disability, and economic hardship worldwide, particularly in low- and middle-income countries. While many of these diseases are targeted for control, elimination, or eradication by 2030, achieving those targets will be challenging due to disruptions to programmes related to the COVID-19 pandemic and differences in disease transmission across regions, which requires tailoring interventions to local settings.
Novel inhaled TB vaccine
General Research
16 January 2024
The Jenner Institute is conducting a new study, using BCG, the current licensed vaccine against tuberculosis. In this study, they will give BCG a second time to people who have already had BCG once before, and will compare whether giving it by inhalation is better at protecting people against tuberculosis than giving it into the skin
First-in-human vaccine trial for deadly Nipah virus launched
Clinical Trials General Research
12 January 2024
First clinical trial participants received doses of the ChAdOx1 NipahB vaccine over the last week at University of Oxford. UK trial is first step to developing a vaccine against Nipah virus – a devastating disease mostly found in South-East Asia – that can be fatal in up to 75% of cases. The milestone clinical trial comes as the global health community marks the 25th anniversary of the first Nipah virus outbreaks. There are still no approved vaccines or treatments for the disease.
Malaria chemoprevention after hospital discharge reduced mortality and sickness in children recovering from severe anaemia
General Research
19 December 2023
A systematic review and individual patient meta-analysis found that malaria chemoprevention after hospital discharge reduces deaths in children recovering from severe anaemia by 70%, and hospital readmission by 55%.
Early-life diseases linked to lifelong childlessness
General Research
19 December 2023
A ground-breaking study, published in Nature Human Behaviour, reveals a significant association between 74 early-life diseases and the likelihood of remaining childless throughout one's life, with 33 of these diseases prevalent in both women and men.
Report sets out recommendations for reducing inequities and improving care for babies of Asian and Black mothers
General Research
14 December 2023
The Mothers and Babies: Reducing Risk through Audits and Confidential Enquiries across UK (MBRRACE) collaboration, which is co-led by The Infant Mortality and Morbidity Studies (TIMMS) group at the University of Leicester and the Nuffield Department of Population Health's Perinatal Epidemiology Unit (NPEU), has today published the results of a confidential enquiry into the care of Black and Asian babies born in the UK in 2019.
Oxford Vaccine Group, Department of Paediatrics, University of Oxford receives £7.8 million in research funding to fight pandemic and epidemic threats
General Research
13 December 2023
Oxford Vaccine Group (OVG), which led the rapid clinical development of the Oxford vaccine in COVID-19 in the pandemic, has been awarded a total of £7,788,783 by UK Aid for research into the prevention of five dangerous diseases with epidemic or pandemic potential. The awards will fund research into vaccines against: Chikungunya and mayaro virus, Marburg virus, Plague (Yersinia pestis), Q Fever (Coxiella burneti) and Sudan Ebolavirus.
1 in 4 malaria patients in Africa receive suboptimal dose of antimalarial drugs
General Research
11 December 2023
A new study estimates that nearly 1 in 4 people with P. falciparum malaria in Africa are at risk of receiving too low a dose of artemisinin combination therapies (ACTs), increasing the chance of treatment failure and the risk that malarial parasites develop resistance to the drug they were exposed to.
Antibiotic resistance genes are spread more widely between bacteria than previously thought
General Research
8 December 2023
A new study published in The Lancet Microbe has found that the transfer of antibiotic resistance genes between different bacteria is considerably more widespread than previously thought.
Race to cure type 1 diabetes gets a new boost
General Research
7 December 2023
Radcliffe Department of Medicine (RDM) group awarded £2.55 million for diabetes research.
The Global Health Network launch The 1000 Challenge
General Research
30 November 2023
The Global Health Network and Nursing Now Challenge launch The 1000 Challenge, a global research leadership initiative to enable health professionals to ask locally important questions to generate evidence. The initiative aims to change practice and management to improve patient management, care, or treatment in a commitment to advance Health for All.
Small cash incentives improve vaccine uptake in rural areas of African countries
Coronavirus General Research
27 November 2023
Researchers from the University of Ghana and Oxford University, including researchers from Oxford Population Health’s Health Economics Research Centre, have shown that small cash incentives increased COVID-19 vaccine uptake in rural Ghana. The findings, published in Nature Medicine, could offer a new strategy for enhancing health interventions in Africa.
Oxford-Harrington Rare Disease Centre named in first global initiative for children with rare diseases
General Research
27 November 2023
In the autumn statement on Wednesday 22 November, the government announced its support for the Rare Therapies Launch Pad, a new programme that will develop regulatory pathways for children with rare conditions to access individualised therapies.
Study reveals barriers to Hepatitis C care in Vietnam’s public healthcare
General Research
24 November 2023
A recent study led by OUCRU researchers highlighted the factors associated with the number of visits to one tertiary public hospital (Hospital for Tropical Diseases in Ho Chi Minh City) that serves as the referral clinic for two-thirds of Vietnam for Hepatitis C virus treatment.
Stronger tobacco control measures needed to halt rising burden of premature deaths from smoking-related diseases in China
General Research
23 November 2023
A study led by researchers from Oxford Population Health has described the long-term impact of cigarette consumption in China and assessed the implementation of five key tobacco control strategies advocated by the World Health Organization (WHO). The review is published in The Lancet Public Health.
Oxford-led study shows how AI can detect antibiotic resistance in as little as 30 minutes
General Research
21 November 2023
To mark World Antimicrobial Awareness Week, researchers supported by the Oxford Martin Programme on Antimicrobial Resistance Testing at the University of Oxford have reported advances towards a novel and rapid antimicrobial susceptibility test that can return results within as little as 30 minutes - significantly faster than current gold-standard approaches.
Call for applications to establish networks of epidemic and pandemic sciences research excellence across Africa
General Research
16 November 2023
The Pandemic Sciences Institute (PSI) has joined forces with the Science for Africa Foundation and the Mastercard Foundation to launch a call for applications to establish innovative networks of research excellence in epidemic and pandemic sciences across Africa.
£4.3m boost for Oxford-Glasgow spinout tackling antimicrobial resistance
Innovation Research
15 November 2023
Glox Therapeutics, a company pioneering the development of precision antibiotics to combat antimicrobial resistance, has raised £4.3M in early-stage funding to develop effective targeted therapeutics against antibiotic-resistant gram-negative bacteria.
Prof Anna Schuh launches first private specialised haematology clinic and laboratory in sub-Saharan Africa
Research
6 November 2023
SerenOx Africa aims to address diagnostic gaps for common blood disorders through a testing facility for key underserved patient populations in Tanzania. This facility will also aim to provide early cancer detection for high-risk patients.
CEPI and University of Oxford advance vaccine work against potentially deadly Arenaviruses
Research
6 November 2023
CEPI will provide up to $25 million to the University of Oxford to complete early development of prototype vaccines against the Junín virus, while also looking to improve manufacturing speed and scale-up of ChAdOx technology. Learnings could be leveraged to inform vaccine design for related viruses from the Arenavirus family, giving the world a head start in rapidly responding to future outbreaks in as little as 100 days. First project to be initiated under CEPI and University of Oxford’s strategic partnership to accelerate global pandemic preparedness efforts.