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This study investigated the comparative accuracy of a recombinant 56-kDa type-specific antigen-based rapid diagnostic test (RDT) for scrub typhus for the detection of IgM antibodies by using conventional serology in well-characterized serum samples from undifferentiated febrile illness patients. The RDT showed high specificity and promising comparative accuracy, with 82% sensitivity and 98% specificity for samples defined positive at an IgM indirect immunofluorescence assay positivity cutoff titer of ≥1:1,600 versus 92% and 95% at ≥1:6,400, respectively.

Original publication




Journal article


Clin Vaccine Immunol

Publication Date





1130 - 1132


Aged, Antibodies, Bacterial, Antigens, Bacterial, Chromatography, Affinity, Female, Fluorescent Antibody Technique, Indirect, Humans, Immunoglobulin M, Male, Orientia tsutsugamushi, Reagent Kits, Diagnostic, Scrub Typhus, Sensitivity and Specificity, Serologic Tests