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The level of plasma soluble ICAM-1 (sICAM-1) has been associated with the pathogenesis of several diseases. Previously, a commercial antibody was reported not to recognize an ICAM-1 allele known as ICAM-1kilifi prevalent among African populations. However, that study was based on 19 samples from African Americans of whom 13 had the wild type allele, five heterozygotes and one homozygote. Here, we compare plasma sICAM-1 measures using three different commercial antibodies in samples from Kenyan children genotyped for ICAM-1kilifi allele. We show that two of these antibodies have some degree of deficiency in detecting the ICAM-1kilifi allele. Consideration of the antibody used to measure sICAM-1 is important as up to 30% of the populations in Africa harbour this allele.

Original publication

DOI

10.1371/journal.pone.0108956

Type

Journal article

Journal

PLoS One

Publication Date

2014

Volume

9

Keywords

Alleles, Blacks, Female, Genotype, Humans, Intercellular Adhesion Molecule-1, Kenya, Male, Polymorphism, Genetic, Population Surveillance