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Many viruses establish life-long infections in their natural host with few if any clinical manifestations. The relationship between virus and host is a dynamic process in which the virus has evolved the means to coexist by reducing its visibility, while the host immune system attempts to suppress and eliminate infection without damage to itself. This short review describes a variety of strategies that are employed by viruses to evade host immune responses. These include virus-associated escape from T cell recognition, and resistance to apoptosis and counterattack, with special reference to two papers published in this issue of Immunity (Mueller et al., 2001; Raftery et al., 2001).

Original publication

DOI

10.1016/s1074-7613(01)00255-2

Type

Journal article

Journal

Immunity

Publication Date

12/2001

Volume

15

Pages

867 - 870

Keywords

Animals, Apoptosis, HIV, Herpesviridae, Humans, Models, Biological, T-Lymphocytes, Cytotoxic, Viral Proteins, Virus Diseases, Virus Latency, Virus Physiological Phenomena