STK Receptor Tyrosine Kinase Regulates Susceptibility to Infection withListeria monocytogenes
Lutz MA., Gervais F., Bernstein A., Hattel AL., Correll PH.
ABSTRACTWe have previously identified the STK receptor tyrosine kinase as a key regulator of macrophage activation and cell-mediated immune responses. Here we demonstrate that, although MSP activation of STK inhibits NO production by macrophages in response to heat-killedListeria monocytogenes,STK-deficient mice exhibit increased susceptibility to infection withListeria.