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BACKGROUND: Previously, the Vi-typhoid conjugate vaccine (Vi-TT) was found to be highly efficacious in Nepalese children under 16 years of age. We assessed the immunogenicity of Vi-TT at 9 and 12 months of age and response to a booster dose at 15 months of age. METHODS: Infants were recruited at Patan Hospital, Kathmandu and received an initial dose of Vi-TT at 9 or 12 months of age with a booster dose at 15 months of age. Blood was taken at four timepoints, and antibody titres were measured using a commercial ELISA kit. The primary study outcome was seroconversion (4-fold rise in antibody titre) of IgG one month after both the doses. FINDINGS: Fifty children were recruited to each study group.Some visits were disrupted by the COVID19 pandemic and occurred out of protocol windows.Both the study groups attained 100 % IgG seroconversion after the initial dose. IgG seroconversion in the 9-month group was significantly higher than in the 12-month group (68.42 % vs 25.8 %, p 

Original publication

DOI

10.1016/j.vaccine.2024.02.010

Type

Journal article

Journal

Vaccine

Publication Date

19/03/2024

Volume

42

Pages

2018 - 2025

Keywords

Booster, Conjugate, Nepal, Typhoid, Vaccine, Child, Infant, Humans, Typhoid Fever, Vaccines, Conjugate, Typhoid-Paratyphoid Vaccines, Nepal, Immunity, Immunoglobulin G, Antibodies, Bacterial, Immunogenicity, Vaccine