Substrate selectivity and inhibition of histidine JmjC hydroxylases MINA53 and NO66
Türkmen VA., Hintzen JCJ., Tumber A., Moesgaard L., Salah E., Kongsted J., Schofield CJ., Mecinović J.
Ribosomal histidine hydroxylases MINA53 and NO66 exhibit narrow substrate selectivities for ribosomal protein L27a/L8 peptides possessing histidine analogues. Selected Rpl peptides display potent inhibition against MINA53 and NO66, providing a basis for inhibitor design.