Multi-ancestry genome-wide association study of gestational diabetes mellitus highlights genetic links with type 2 diabetes.
Pervjakova N., Moen G-H., Borges M-C., Ferreira T., Cook JP., Allard C., Beaumont RN., Canouil M., Hatem G., Heiskala A., Joensuu A., Karhunen V., Kwak SH., Lin FTJ., Liu J., Rifas-Shiman S., Tam CH., Tam WH., Thorleifsson G., Andrew T., Auvinen J., Bhowmik B., Bonnefond A., Delahaye F., Demirkan A., Froguel P., Haller-Kikkatalo K., Hardardottir H., Hummel S., Hussain A., Kajantie E., Keikkala E., Khamis A., Lahti J., Lekva T., Mustaniemi S., Sommer C., Tagoma A., Tzala E., Uibo R., Vääräsmäki M., Villa PM., Birkeland KI., Bouchard L., Duijn CM., Finer S., Groop L., Hämäläinen E., Hayes GM., Hitman GA., Jang HC., Järvelin M-R., Jenum AK., Laivuori H., Ma RC., Melander O., Oken E., Park KS., Perron P., Prasad RB., Qvigstad E., Sebert S., Stefansson K., Steinthorsdottir V., Tuomi T., Hivert M-F., Franks PW., McCarthy MI., Lindgren CM., Freathy RM., Lawlor DA., Morris AP., Mägi R.
Gestational diabetes mellitus (GDM) is associated with increased risk of pregnancy complications and adverse perinatal outcomes. GDM often reoccurs and is associated with increased risk of subsequent diagnosis of type 2 diabetes (T2D). To improve our understanding of the aetiological factors and molecular processes driving the occurrence of GDM, including the extent to which these overlap with T2D pathophysiology, the GENetics of Diabetes In Pregnancy (GenDIP) Consortium assembled genome-wide association studies (GWAS) of diverse ancestry in a total of 5485 women with GDM and 347 856 without GDM. Through multi-ancestry meta-analysis, we identified five loci with genome-wide significant association (p