Adenovirus vectors activate Vδ2+ γδT cells in a type I interferon-, TNF-, and IL-18-dependent manner.
Provine NM., Amini A., Garner LC., FitzPatrick MEB., Dold C., Silva Reyes L., Chinnakannan S., Oguti B., Raymond M., Troise F., Capone S., Folgori A., Barnes E., Rollier CS., Pollard AJ., Klenerman P.
Vδ2+ γδT cells are unconventional T cells that can be activated by cytokines without TCR signaling. Adenovirus vaccine vectors activated Vδ2+ γδT cells in an interleukin 18-, TNF-, and type I interferon-dependent manner. This stimulatory capacity was associated with adenovirus vectors of non-species C origin, including the ChAdOx1 vaccine platform.