Professor C Louise Thwaites
Contact information
Websites
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VITAL project
The VITAL project aims to reduce morbidity and mortality from infectious diseases in Asia by using innovative technology and clinical approaches
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PHENOM-AI
PHENOM-AI aims to develop AI-powered tools, wearables, and immune profiling techniques to improve pneumonia diagnosis and treatment in resource-limited intensive care settings worldwide for ill patients.
Colleges
C Louise Thwaites
BSc MBBS MRCP MD DMSMed MLCOM
Professor of Experimental Critical Care
- Senior Clinical Research Fellow
Emerging Infection
Professor Louise Thwaites is a clinical researcher and expert in critical care and emerging infections, with appointments at the Centre for Tropical Medicine and Global Health, University of Oxford, and the Oxford University Clinical Research Unit (OUCRU) in Ho Chi Minh City, Vietnam. She holds a Research Fellowship at Linacre College.
Her work focuses on improving outcomes for critically ill patients in resource-limited settings. She has longstanding research interests in severe infectious diseases, including tetanus, sepsis, dengue and pneumonia, and has led major clinical trials, including studies of magnesium sulphate and intrathecal antitoxin in tetanus.
Her research programme aims to advance the diagnosis and management of severe infections through innovative technologies adapted for low-resource environments. This includes the application of wearable physiological monitoring and artificial intelligence–based risk prediction in the VITAL project. She currently leads PHENOM-AI, a multidisciplinary UK–Vietnam collaboration integrating artificial intelligence, advanced pathogen identification and immune profiling to better characterise pneumonia and inform future diagnostic and treatment strategies.
Professor Thwaites is a board member of the BMJ Future Health initiative, and plays an active role in international guideline and policy development. She is a member of the Asia Pacific Sepsis Association and contributes to the Sepsis in Resource-Limited Settings Consensus Group of the European Society of Intensive Care Medicine. She serves as an expert consultant to the World Health Organization (WHO), is a member of the WHO advisory group for COVID-19 Clinical Management Living Guidelines, the WHO Global Clinical Platform Technical Advisory Group, and the WHO O2ptimising Respiratory Care Working Group. She is also a board member of the BMJ Future Health initiative.
Key publications
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Classification of Tetanus Severity in Intensive-Care Settings for Low-Income Countries Using Wearable Sensing.
Journal article
Lu P. et al, (2022), Sensors (Basel), 22
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Evaluation of awake prone positioning effectiveness in moderate to severe COVID-19
Journal article
Truong NT. et al, (2023), Wellcome Open Research, 8, 235 - 235
Recent publications
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High immunisation coverage but sporadic outbreaks of vaccine-preventable diseases: the structural gaps in vaccination uptake in central highlands, Vietnam.
Journal article
Nguyen TH. et al, (2025), BMC Public Health, 25
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Molnupiravir or nirmatrelvir-ritonavir plus usual care versus usual care alone in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.
Journal article
RECOVERY Collaborative Group None., (2025), Lancet Infect Dis
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Evidence based QUality Improvement for Prescribing Stewardship in ICU (EQUIPS-ICU): protocol for type III hybrid implementation-effectiveness study.
Journal article
Wagstaff D. et al, (2025), Implement Sci, 20
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Status of Digital Health Technology Adoption in 5 Vietnamese Hospitals: Cross-Sectional Assessment.
Journal article
Tran DM. et al, (2025), JMIR Form Res, 9
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Management of adult sepsis in resource-limited settings: global expert consensus statements using a Delphi method.
Journal article
Thwaites L. et al, (2025), Intensive Care Med, 51, 21 - 38
