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A 51-year-old man presented with intermittent fever, mild cough and loss of appetite of 1-month duration. His sputum smear was positive for acid-fast bacilli and his chest radiograph revealed apical infiltrations. The patient was treated with antitubercular therapy (ATT), recovered and was well for 1 month, after which he suddenly developed focal seizures. MRI of the brain with gadolinium enhancement showed high intensity nodular foci in the frontal, parietal and occipital regions. The patient was diagnosed as a case of paradoxical reaction to ATT, and was successfully managed with continued ATT and adjunctive steroid therapy.

Original publication




Journal article


BMJ Case Rep

Publication Date





Antitubercular Agents, Brain, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Radiography, Thoracic, Seizures, Tuberculosis, Central Nervous System, Tuberculosis, Pulmonary