Proteo-genomic analyses in relatively lean Chinese adults identify proteins and pathways that affect general and central adiposity levels.

Iona A., Yao P., Pozarickij A., Kartsonaki C., Said S., Wright N., Lin K., Millwood I., Fry H., Mazidi M., Wang B., Chen Y., Du H., Yang L., Avery D., Schmidt D., Sun D., Pei P., Lv J., Yu C., Hill M., Chen J., Bragg F., Bennett D., Walters R., Li L., Clarke R., Chen Z., China Kadoorie Biobank Collaborative Group None.

Adiposity is an established risk factor for multiple diseases, but the causal relationships of different adiposity types with circulating protein biomarkers have not been systematically investigated. We examine the causal associations of general and central adiposity with 2923 plasma proteins among 3977 Chinese adults (mean BMI = 23.9 kg/m²). Genetically-predicted body mass index (BMI), body fat percentage (BF%), waist circumference (WC), and waist-to-hip ratio (WHR) are significantly (FDR 

DOI

10.1038/s42003-024-06984-y

Type

Journal article

Journal

Commun Biol

Publication Date

15/10/2024

Volume

7

Keywords

Humans, Adiposity, Male, Female, Adult, Asian People, Middle Aged, Genome-Wide Association Study, Mendelian Randomization Analysis, Quantitative Trait Loci, Proteomics, China, Body Mass Index, Thinness, Obesity, Abdominal, Genomics, Blood Proteins, Waist-Hip Ratio, Biomarkers, East Asian People

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