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10 000 electrophilic compounds were screened for inhibition of the essential l,d-transpeptidase (LdtMt2) of Mycobacterium tuberculosis. Potent covalently reacting inhibitors were identified and characterised by protein X-ray and MS studies.

Original publication

DOI

10.1039/d2sc06858c

Type

Journal article

Journal

Chemical Science

Publisher

Royal Society of Chemistry (RSC)

Publication Date

2023