High-throughput screen with the l,d-transpeptidase LdtMt2 of Mycobacterium tuberculosis reveals novel classes of covalently reacting inhibitors
de Munnik M., Lang PA., De Dios Anton F., Cacho M., Bates RH., Brem J., Rodríguez Miquel B., Schofield CJ.
10 000 electrophilic compounds were screened for inhibition of the essential l,d-transpeptidase (LdtMt2) of Mycobacterium tuberculosis. Potent covalently reacting inhibitors were identified and characterised by protein X-ray and MS studies.