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BACKGROUND: Alpha-glucosidase inhibitors (AGIs) have been shown to reduce incident type 2 diabetes but their impact on cardiovascular (CV) disease remains controversial. We sought to identify the overall impact of AGIs with respect to incident type 2 diabetes in individuals with impaired glucose tolerance (IGT), and CV outcomes in those with IGT or type 2 diabetes. METHODS: We used PubMed and SCOPUS to identify randomized controlled trials reporting the incidence of type 2 diabetes and/or CV outcomes that had compared AGIs with placebo in populations with IGT or type 2 diabetes, with or without established CV disease. Eligible studies were required to have ≥ 500 participants and/or ≥ 100 endpoints of interest. Meta-analyses of available trial data were performed using random effects models to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) for incident type 2 diabetes and CV outcomes. RESULTS: Of ten trials identified, three met our inclusion criteria for incident type 2 diabetes and four were eligible for CV outcomes. The overall HR (95% CI) comparing AGI with placebo for incident type 2 diabetes was 0.77 (0.67-0.88), p 

Original publication




Journal article


Cardiovasc Diabetol

Publication Date





Alpha glucosidase inhibitor, Cardiovascular disease, Impaired glucose tolerance, Meta-analysis, Type 2 diabetes, Aged, Cardiovascular Diseases, Diabetes Mellitus, Type 2, Female, Glucose Intolerance, Glycoside Hydrolase Inhibitors, Humans, Incidence, Male, Middle Aged, Randomized Controlled Trials as Topic, Risk Assessment, Risk Factors, Treatment Outcome